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Structure of 59702-07-7
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1-Methylpiperazin-2-one features a rigid, electron-deficient heterocyclic core that enhances metabolic stability and improves membrane permeability. This scaffold integrates readily into bioactive molecules, serving as a key amide-isostere in medicinal chemistry. Its bench-stable nature facilitates handling under standard conditions.
1-Methylpiperazin-2-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to diverse pharmacophores. Its amide functionality and nitrogen-rich framework facilitate conjugation in Suzuki-Miyaura and Buchwald-Hartwig couplings, while the piperazinone core offers favorable solubility and metabolic stability. Bench-stable and readily purified by chromatography, it functions as a key scaffold for targeted synthesis of kinase inhibitors and CNS-active compounds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: