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CS-W001157 4
Total: USD 88.00

Bis-PEG1-acid

  • CAS No. 5961-83-1

  • Cat. No. CS-0046419
  • Purity≥96%
  • MDL No.MFCD06208032

*For research and further manufacturing use only, not for direct human use.

Bis-PEG1-acid|CS-0046419

Structure of 5961-83-1

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General Information

  • CAS No. 5961-83-1
  • Cat. No. CS-0046419
  • Purity ≥96%
  • MDL No. MFCD06208032
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₅
  • Molecular Weight 162.14
  • Synonym(s) None
  • SMILES O=C(O)CCOCCC(O)=O

Description

Bis-PEG1-acid features two terminal carboxylic acid groups flanking a short polyethylene glycol spacer, enabling efficient conjugation in bioconjugation workflows. This bifunctional linker offers enhanced solubility and stability under physiological conditions, facilitating site-specific labeling of biomolecules with minimal aggregation.

Application

Bis-PEG1-acid serves as a versatile bifunctional linker for conjugation and polymer synthesis, enabling efficient coupling of biomolecules, drugs, or functionalized surfaces via amine or hydroxyl groups. Its PEG1 spacer provides enhanced solubility and reduced non-specific binding, while the terminal carboxylic acid groups offer straightforward activation for NHS ester or amide formation. Ideal for modular synthesis and bioconjugation workflows requiring stability and controlled spacing.

Synthesis

  • Route1
    • null|null
      79-10-7
    • ~4%
    • In-stock
      Bis-PEG1-acid|CS-0046419
      5961-83-1
    • In-stock
      3-Hydroxypropionic acid 30% in water|CS-0147832
      503-66-2

    References

    • CARGILL INCORPORATED Patent: WO2004/76398 A1, 2004 ; Location in patent: Page 8 ;
  • Route2

    References

    • Landeros, Jose M.; Silvestre, Hugo A.; Guadarrama, Patricia Journal of Molecular Structure, 2013 , vol. 1037, p. 412 - 419
  • Route3
    • null|null
      1656-48-0
    • ~92%
    • In-stock
      Bis-PEG1-acid|CS-0046419
      5961-83-1

    References

    • Buchanan; Driega; Yap Canadian Journal of Chemistry, 2000 , vol. 78, # 3 p. 316 - 321

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   83.83
  • LogP   -0.0476
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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