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CS-W001157 4
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Tetraethyl heptane-1,7-diylbis(phosphonate)

  • CAS No. 5943-17-9

  • Cat. No. CS-0115759
  • Molecule weight372.37
  • Purity≥98%
  • MDL No.MFCD24539458

*For research and further manufacturing use only, not for direct human use.

Tetraethyl heptane-1,7-diylbis(phosphonate)|CS-0115759

Structure of 5943-17-9

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General Information

  • CAS No. 5943-17-9
  • Cat. No. CS-0115759
  • Purity ≥98%
  • MDL No. MFCD24539458
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₃₄O₆P₂
  • Molecular Weight 372.37
  • Synonym(s) None
  • SMILES O=P(CCCCCCCP(OCC)(OCC)=O)(OCC)OCC

Description

PIPES is a member of the ethanesulfonic acid buffer series, first introduced by Good et al., developed to meet certain criteria: midrange pKa, maximum water solubility and minimum solubility in all other solvents, minimal salt effects, minimal change in pKa with temperature, chemically and enzymatically stable, minimal absorption in visible or UV spectral range and easily synthesized. Since its pKa at 37 C is near physiological pH, PIPES has applications in cell culture work.Glutaraldehyde fixation of plant and animal tissue samples can cause loss of lipid, leading to apparent morphological changes. Lipid loss and artifacts were minimized when PIPES was used to buffer the glutaraldehyde fixative.,Alkaline phosphatase activity is lost selectively from certain rat hepatocyte organelles when fixed for ultracytochemistry with cacodylate-buffered glutaraldehyde. When PIPES was used as buffer, retention of activity was 60% greater. Fixation of fungal zoospores for fluorescence microscopy and electron microscopy was optimal with a combination of glutaraldehyde and formaldehyde in PIPES buffer.

Synthesis

  • Route1

    References

    • Kosolapoff,G.M.; Brown,A.D. Journal of the Chemical Society [Section] C: Organic, 1966 , p. 757 - 759

Safety Information

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Computational Chemistry Data

  • TPSA   71.06
  • LogP   5.4691
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   16

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