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CS-W001157 4
Total: USD 88.00

4-(Trifluoromethyl)picolinic acid

  • CAS No. 588702-62-9

  • Cat. No. CS-W015853
  • Molecule weight191.11
  • Purity≥97%
  • MDL No.MFCD07438043

*For research and further manufacturing use only, not for direct human use.

4-(Trifluoromethyl)picolinic acid|CS-W015853

Structure of 588702-62-9

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General Information

  • CAS No. 588702-62-9
  • Cat. No. CS-W015853
  • Purity ≥97%
  • MDL No. MFCD07438043
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄F₃NO₂
  • Molecular Weight 191.11
  • Synonym(s) 4-Trifluoromethyl-2-picolinic acid
  • SMILES O=C(O)C1=NC=CC(C(F)(F)F)=C1

Description

4-(Trifluoromethyl)picolinic acid features a trifluoromethyl group at the para position of the picolinic ring, enhancing electron-withdrawal and metabolic stability. This structural motif enables efficient coupling in amide bond formation, particularly in peptide synthesis and medicinal chemistry applications. The compound exhibits robust bench-stability and solubility under standard conditions.

Application

4-(Trifluoromethyl)picolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the pyridine carboxylic acid functionality facilitates straightforward derivatization via amide formation, esterification, or metal-catalyzed coupling reactions. The compound exhibits excellent bench stability and compatibility with standard purification protocols, making it well-suited for scalable synthetic applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.7986
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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