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CS-W001157 4
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4-(Difluoromethyl)picolinic acid

  • CAS No. 1256804-49-5

  • Cat. No. CS-0100028
  • Molecule weight173.12
  • Purity≥98%
  • MDL No.MFCD18256210

*For research and further manufacturing use only, not for direct human use.

4-(Difluoromethyl)picolinic acid|CS-0100028

Structure of 1256804-49-5

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General Information

  • CAS No. 1256804-49-5
  • Cat. No. CS-0100028
  • Purity ≥98%
  • MDL No. MFCD18256210
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO₂
  • Molecular Weight 173.12
  • Synonym(s) 4-(DIFLUOROMETHYL)PYRIDINE-2-CARBOXYLIC ACID
  • SMILES OC(C1=NC=CC(C(F)F)=C1)=O

Description

4-(Difluoromethyl)picolinic acid features a strategically positioned difluoromethyl group on the pyridine ring, enhancing electronic withdrawal and metabolic stability. This electron-deficient heterocycle integrates readily into bioactive scaffolds, enabling direct incorporation into pharmaceutical intermediates and ligand designs through robust coupling protocols under standard conditions.

Application

4-(Difluoromethyl)picolinic acid serves as a versatile building block in medicinal chemistry, enabling the incorporation of a metabolically stable difluoromethyl group into bioactive molecules. Its pyridine carboxylic acid scaffold facilitates direct amidation, esterification, and coupling reactions, while the difluoromethyl moiety imparts enhanced lipophilicity and resistance to oxidative metabolism. The compound exhibits excellent bench stability and compatibility with standard purification techniques, making it ideal for high-throughput synthesis and lead optimization campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.7174
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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