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CS-W001157 4
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5-Fluoro-2-methoxypyridin-4-amine

  • CAS No. 58381-05-8

  • Cat. No. CS-0005587
  • Molecule weight142.13
  • Purity≥95%
  • MDL No.MFCD16606165

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-methoxypyridin-4-amine|CS-0005587

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General Information

  • CAS No. 58381-05-8
  • Cat. No. CS-0005587
  • Purity ≥95%
  • MDL No. MFCD16606165
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇FN₂O
  • Molecular Weight 142.13
  • Synonym(s) 5-Fluoro-2-methoxy-4-pyridinamine
  • SMILES NC1=CC(OC)=NC=C1F

Description

5-Fluoro-2-methoxypyridin-4-amine features a strategically positioned fluorine atom and methoxy group on the pyridine ring, enhancing electron-withdrawing character and enabling selective functionalization. This bench-stable heterocycle integrates readily into pharmaceutical scaffolds, serving as a key building block for kinase inhibitors and bioactive nitrogen-containing compounds under standard coupling conditions.

Application

5-Fluoro-2-methoxypyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based pharmacophores. Its fluorine and amine functionalities facilitate downstream coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig couplings, while the methoxy group provides orthogonal reactivity and enhanced solubility. Bench-stable and readily purified, it supports scalable synthesis of kinase inhibitors and other bioactive heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.8115
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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