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CS-W001157 4
Total: USD 88.00

Topiroxostat

  • CAS No. 577778-58-6

  • Cat. No. CS-2033
  • Purity≥99%
  • MDL No.MFCD17167057

*For research and further manufacturing use only, not for direct human use.

Topiroxostat|CS-2033

Structure of 577778-58-6

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General Information

  • CAS No. 577778-58-6
  • Cat. No. CS-2033
  • Purity ≥99%
  • MDL No. MFCD17167057
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₈N₆
  • Molecular Weight 248.24
  • Synonym(s) FYX-051
  • SMILES N#CC1=NC=CC(C2=NNC(C3=CC=NC=C3)=N2)=C1

Description

Topiroxostat is a potent, selective inhibitor of xanthine oxidase, designed to reduce uric acid production in hyperuricemic conditions. This small molecule features a unique pyrazolo[1,5-a]pyrimidine core that enables tight binding to the enzyme's active site. It exhibits favorable metabolic stability and oral bioavailability, making it suitable for chronic dosing regimens. The compound demonstrates efficacy in lowering serum uric acid levels under standard conditions.

Application

Topiroxostat serves as a potent, selective inhibitor of xanthine oxidase, enabling precise modulation of uric acid biosynthesis. Its well-defined structure facilitates reliable use in metabolic studies and preclinical research. The compound exhibits favorable bench stability and compatibility with standard assay workflows, supporting consistent performance in enzymatic inhibition profiling and pharmacodynamic evaluation.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   91.14
  • LogP   1.80038
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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