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Structure of 57775-06-1
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This nitrile features a sterically hindered quaternary carbon bearing a bromophenyl group, enabling direct functionalization in palladium-catalyzed cross-coupling reactions. The para-bromine facilitates Suzuki-Miyaura and Negishi couplings under standard conditions, while the electron-withdrawing nitrile enhances reactivity at the benzylic position. Bench-stable and moisture-tolerant, it serves as a key intermediate for complex heterocyclic architectures.
2-(2-Bromophenyl)-2-methylpropanenitrile serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl scaffolds. The nitrile group provides a handle for downstream functionalization, while the geminal methyl groups enhance stability and facilitate purification. Its bench-stable nature and compatibility with palladium-catalyzed coupling protocols make it a practical choice for synthesizing complex pharmaceutical intermediates and functionalized heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: