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Structure of 57631-05-7
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3-(Trifluoromethyl)-1H-indazole is a bench-stable, electron-deficient heterocycle featuring a trifluoromethyl group at the 3-position, enhancing metabolic stability and lipophilicity. This configuration enables direct functionalization in cross-coupling reactions and facilitates incorporation into bioactive molecules for medicinal chemistry applications.
3-(Trifluoromethyl)-1H-indazole serves as a valuable heterocyclic building block in medicinal chemistry, offering enhanced metabolic stability and modulated lipophilicity due to the electron-withdrawing trifluoromethyl group. It functions as a bioisostere for phenyl or pyridine moieties in drug discovery campaigns and participates reliably in standard coupling reactions, including Pd-catalyzed cross-couplings and electrophilic substitutions. The compound exhibits good bench stability and facilitates efficient synthesis of complex scaffolds under routine laboratory conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: