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CS-W001157 4
Total: USD 88.00

4-Chloro-7-methoxyquinazolin-6-ol Gefitinib Impurity

  • CAS No. 574745-97-4

  • Cat. No. CS-0167149
  • Purity≥98%
  • MDL No.MFCD12547341

*For research and further manufacturing use only, not for direct human use.

4-Chloro-7-methoxyquinazolin-6-ol Gefitinib Impurity|CS-0167149

Structure of 574745-97-4

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General Information

  • CAS No. 574745-97-4
  • Cat. No. CS-0167149
  • Purity ≥98%
  • MDL No. MFCD12547341
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇ClN₂O₂
  • Molecular Weight 210.62
  • Synonym(s) 4-Chloro-6-hydroxy-7-Methoxyquinazoline
  • SMILES OC1=CC2=C(N=CN=C2C=C1OC)Cl

Synthesis

  • Route1

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2005/26151 A1, 2005 ; Location in patent: Page/Page column 124 ; WO 2005/026151 A1
  • Route2
    • null|null
      1276184-25-8
    • ~24%
    • 4-Chloro-7-methoxyquinazolin-6-ol Gefitinib Impurity|CS-0167149
      574745-97-4
    • null|null
      1276184-26-9

    References

    • Pham, Helen Trinh; Hanson, Robert N.; Olmsted, Sandra L.; Kozhushnyan, Anton; Visentin, Adam; Weglinsky, Paul J.; Massero, Chris; Bailey, Kristen Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1053 - 1056
  • Route3

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2004/41829 A1, 2004 ; Location in patent: Page 88 ; WO 2004/041829 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.24
  • LogP   1.9974
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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