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CS-W001157 4
Total: USD 88.00

Benzomorpholine

  • CAS No. 5735-53-5

  • Cat. No. CS-W004783
  • Purity≥97%
  • MDL No.MFCD02181098

*For research and further manufacturing use only, not for direct human use.

Benzomorpholine|CS-W004783

Structure of 5735-53-5

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General Information

  • CAS No. 5735-53-5
  • Cat. No. CS-W004783
  • Purity ≥97%
  • MDL No. MFCD02181098
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO
  • Molecular Weight None
  • Synonym(s) 8-[4-(diphenylmethyl)piperazin-1-yl]-5,17,19,21-tetrahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-1,6,9,11(2H)-tetrone; Benzomorpholine
  • SMILES C12=CC=CC=C1NCCO2

Description

Benzomorpholine features a fused bicyclic core combining benzene and morpholine moieties, offering enhanced rigidity and polarity. This structure supports improved solubility and metabolic stability in medicinal chemistry applications. The nitrogen atom provides a site for derivatization, enabling integration into diverse pharmacophores. Its balanced lipophilicity facilitates membrane permeability while maintaining aqueous solubility.

Application

Benzomorpholine serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling the construction of bioactive molecules through its well-established reactivity in palladium-catalyzed cross-coupling and electrophilic functionalization. Its bench-stable nature and compatibility with diverse protecting groups facilitate efficient synthesis of complex API intermediates.

Synthesis

  • Route1
    • null|null
      106-93-4
    • null|null
      95-55-6
    • ~73%
    • In-stock
      Benzomorpholine|CS-W004783
      5735-53-5

    References

    • Mizar, Pushpak; Myrboh, Bekington Tetrahedron Letters, 2006 , vol. 47, # 44 p. 7823 - 7826
  • Route2
    • 2-((2-Bromophenyl)amino)ethanol|CS-0706835
      87762-20-7
    • ~87%
    • In-stock
      Benzomorpholine|CS-W004783
      5735-53-5

    References

    • Toracca, Karen E.; Kuwabe, Shin-Itsu; Buchwald, Stephen L. Journal of the American Chemical Society, 2000 , vol. 122, # 51 p. 12907 - 12908
  • Route3

    References

    • MEMORY PHARMACEUTICALS CORPORATION Patent: US2008/200471 A1, 2008 ; Location in patent: Page/Page column 47 ; US 20080200471 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   1.4909
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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