Lot numbers can be found on the outside label of a product:
3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol
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CAS No. 26021-57-8
- Cat. No. CS-0155718
- Purity≥98%
- MDL No.MFCD00600394
*For research and further manufacturing use only, not for direct human use.
![3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol|CS-0155718](https://file.chemscene.com/productPIC/CS-0155718.gif)
Structure of 26021-57-8
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General Information
- CAS No. 26021-57-8
- Cat. No. CS-0155718
- Purity ≥98%
- MDL No. MFCD00600394
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₉NO₂
- Molecular Weight 151.16
- Synonym(s) None
- SMILES C1=CC2=C(C=C1O)NCCO2
Description
3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol is a bench-stable heterocyclic scaffold featuring a phenolic hydroxyl group flanked by an oxygen and nitrogen heteroatom within a fused ring system. This electron-rich framework integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds. The hydroxyl moiety enables direct derivatization or hydrogen bonding interactions in binding sites.
Application
3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its hydroxyl group provides a handle for derivatization, while the fused oxazine ring offers structural rigidity and favorable pharmacokinetic properties. The compound exhibits good bench stability and compatibility with standard synthetic transformations, facilitating its use in late-stage functionalization and library synthesis.
Synthesis
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Route1
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![6-Hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one|CS-0085208](https://file.chemscene.com/productPIC/CS-0085208.gif)
53412-38-7 - ~99%
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In-stock
26021-57-8
References
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UNIVERSITY OF MASSACHUSETTS Patent: WO2009/36351 A2, 2009 ; Location in patent: Page/Page column 21; 22/24 ;
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Route2
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In-stock
28226-20-2 - ~76%
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In-stock
26021-57-8
References
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Iakovou, Kriton; Kazanis, Michalis; Vavayannis, Andreas; Bruni, Giancarlo; Romeo, Maria Raffaella; Massarelli, Paola; Teramoto, Shuji; Fujiki, Hiroyuki; Mori, Toyoki European Journal of Medicinal Chemistry, 1999 , vol. 34, # 11 p. 903 - 917
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Route3
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In-stock
102-56-7 - ~%
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In-stock
26021-57-8
References
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Iakovou, Kriton; Kazanis, Michalis; Vavayannis, Andreas; Bruni, Giancarlo; Romeo, Maria Raffaella; Massarelli, Paola; Teramoto, Shuji; Fujiki, Hiroyuki; Mori, Toyoki European Journal of Medicinal Chemistry, 1999 , vol. 34, # 11 p. 903 - 917
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07,GHS09
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H411
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Precautionary Statements : P264-P270-P273-P301+P310-P330-P391-P501
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Quality Control
Computational Chemistry Data
- TPSA 41.49
- LogP 1.1965
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 0
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Key Words
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