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CS-W001157 4
Total: USD 88.00

4-Fluoro-1-naphthoic acid

  • CAS No. 573-03-5

  • Cat. No. CS-W015900
  • Purity≥96%
  • MDL No.MFCD00004011

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-1-naphthoic acid|CS-W015900

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General Information

  • CAS No. 573-03-5
  • Cat. No. CS-W015900
  • Purity ≥96%
  • MDL No. MFCD00004011
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₇FO₂
  • Molecular Weight 190.17
  • Synonym(s) 4-fluoronaphthalene-1-carboxylic acid
  • SMILES OC(=O)C1=CC=C(F)C2=C1C=CC=C2

Description

4-Fluoro-1-naphthoic acid features a fluorine atom at the para position of the naphthoic acid scaffold, enhancing electronic effects and metabolic stability. This bench-stable carboxylic acid integrates readily into synthetic routes requiring electron-deficient aromatic systems, serving as a key building block in pharmaceutical and agrochemical development.

Application

4-Fluoro-1-naphthoic acid serves as a versatile building block in medicinal chemistry and materials science, enabling direct incorporation of fluorinated aromatic functionality. Its carboxylic acid group facilitates standard transformations such as amidation, esterification, and coupling reactions, while the fluoro substituent enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions reliably in multistep syntheses requiring orthogonality and predictable reactivity.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 89, p. 386 - 390
  • Route2

    References

    • Dixon, Elisabeth A.; Fischer, Alfred; Robinson, Frank P. Canadian Journal of Chemistry, 1981 , vol. 59, p. 2629 - 2641
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 89, p. 386 - 390

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.6771
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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