1-Bromo-4-fluoronaphthalene

Name: 1-Bromo-4-fluoronaphthalene
Brand: ChemScene
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CAS No. 341-41-3
Cat. No. CS-W013050
Purity≥97%
MDL No.MFCD00051473

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 341-41-3

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General Information

CAS No. 341-41-3
Cat. No. CS-W013050
Purity ≥97%
MDL No. MFCD00051473
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₆BrF
Molecular Weight 225.06
Synonym(s) 1-FLUORO-4-BROMONAPHTHALENE; 1-Bromo-4-fluoronaphthalene
SMILES FC1=C2C=CC=CC2=C(Br)C=C1

Description

1-Bromo-4-fluoronaphthalene features a strategically positioned bromine and fluorine substituent on the naphthalene core, enabling selective cross-coupling reactions. The electron-deficient aromatic system enhances reactivity in palladium-catalyzed transformations, while the orthogonal functional groups allow sequential derivatization. This bench-stable compound integrates readily into complex molecular architectures.

Application

1-Bromo-4-fluoronaphthalene serves as a versatile building block in cross-coupling reactions, enabling efficient C–C bond formation via palladium-catalyzed methodologies. The orthogonal reactivity of bromo and fluoro substituents allows sequential functionalization, while the naphthalene core provides structural rigidity and π-conjugation suitable for pharmaceutical and materials applications. Bench-stable and readily purified, it functions reliably in standard synthetic workflows.

Synthesis

Route1
- In-stock
  
  321-38-0
- ~60%
- In-stock
  
  341-41-3
References
- Lowe III, John A.; Qian, Weimin; Drozda, Susan E.; Volkmann, Robert A.; Nason, Deane; Nelson, Robert B.; Nolan, Charles; Liston, Dane; Ward, Karen; Faraci, Steve; Verdries, Kim; Seymour, Pat; Majchrzak, Michael; Villalobos, Anabella; White, W. Frost Journal of Medicinal Chemistry, 2004 , vol. 47, # 6 p. 1575 - 1586
Route2
- 56-23-5
- In-stock
  
  321-38-0
- 7726-95-6
- ~%
- In-stock
  
  341-41-3
References
- Justus Liebigs Annalen der Chemie, , vol. 487, p. 270,282

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 0
LogP 3.7414
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Naphthalene compounds

Key Words

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1-Bromo-4-fluoronaphthalene

CAS No. 341-41-3

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