Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Ethynyl-1H-pyrazole

  • CAS No. 57121-49-0

  • Cat. No. CS-0034022
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Ethynyl-1H-pyrazole|CS-0034022

Structure of 57121-49-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 57121-49-0
  • Cat. No. CS-0034022
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₂
  • Molecular Weight 92.10
  • Synonym(s) None
  • SMILES C#CC1=CNN=C1

Description

4-Ethynyl-1H-pyrazole features a reactive alkyne handle positioned at the 4-position of a stable pyrazole scaffold. This configuration enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and click chemistry applications. The electron-deficient heterocycle enhances regioselectivity in cyclization reactions, while the terminal alkyne supports straightforward derivatization under mild conditions.

Application

4-Ethynyl-1H-pyrazole serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to functionalized pyrazole scaffolds. Its terminal alkyne group facilitates reliable Sonogashira and CuAAC transformations, offering high chemoselectivity and compatibility with diverse functional groups. The compound exhibits excellent bench stability and is readily purified by standard chromatographic methods, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • 4-((Trimethylsilyl)ethynyl)-1H-pyrazole|CS-1348495
      900164-93-4
    • ~99%
    • In-stock
      4-Ethynyl-1H-pyrazole|CS-0034022
      57121-49-0

    References

    • GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; HANAN, Emily; HEFFRON, Timothy; PURKEY, Hans; ELLIOTT, Richard Leonard; HEALD, Robert; KNIGHT, Jamie; LAINCHBURY, Michael; SEWARD, Eileen M. Patent: WO2014/81718 A1, 2014 ; Location in patent: Page/Page column 39 ;
  • Route2
    • null|null
      959918-26-4
    • ~95%
    • In-stock
      4-Ethynyl-1H-pyrazole|CS-0034022
      57121-49-0

    References

    • UCB PHARMA S.A. Patent: WO2007/141504 A1, 2007 ; Location in patent: Page/Page column 61 ; WO 2007/141504 A1
  • Route3
    • null|null
      82099-91-0
    • ~69%
    • In-stock
      4-Ethynyl-1H-pyrazole|CS-0034022
      57121-49-0

    References

    • Tolf, Bo-Ragnar; Dahlbom, Richard; Theorell, Hugo; Akeson, Ake Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982 , vol. 36, # 2 p. 101 - 108

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P403-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   28.68
  • LogP   0.391
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4-Ethynyl-1H-pyrazole sigma4-Ethynyl-1H-pyrazole manufacturer4-Ethynyl-1H-pyrazole price4-Ethynyl-1H-pyrazole structure4-Ethynyl-1H-pyrazole SDSbuy 4-Ethynyl-1H-pyrazole4-Ethynyl-1H-pyrazole supplier4-Ethynyl-1H-pyrazole uses4-Ethynyl-1H-pyrazole molecular weightprice of 4-Ethynyl-1H-pyrazole4-Ethynyl-1H-pyrazole chemical name formula of 4-Ethynyl-1H-pyrazole
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label