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CS-W001157 4
Total: USD 88.00

3-Methoxy-5-(trifluoromethyl)phenol

  • CAS No. 349-56-4

  • Cat. No. CS-W021953
  • Purity≥98%
  • MDL No.MFCD09025418

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-5-(trifluoromethyl)phenol|CS-W021953

Structure of 349-56-4

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General Information

  • CAS No. 349-56-4
  • Cat. No. CS-W021953
  • Purity ≥98%
  • MDL No. MFCD09025418
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇F₃O₂
  • Molecular Weight 192.14
  • Synonym(s) 3-Methoxy-5-trifluormethyl-phenol
  • SMILES OC1=CC(C(F)(F)F)=CC(OC)=C1

Description

3-Methoxy-5-(trifluoromethyl)phenol features a trifluoromethyl group that imparts strong electron-withdrawing character, enhancing reactivity in electrophilic substitution. The methoxy substituent contributes resonance donation, balancing electronic effects. This dual-functionalized phenol offers enhanced stability and solubility in organic media, enabling efficient incorporation into pharmaceutical intermediates and advanced materials synthesis under standard conditions.

Application

3-Methoxy-5-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering a strategically positioned trifluoromethyl group for enhanced metabolic stability and lipophilicity. The phenolic hydroxyl enables direct derivatization via etherification or esterification, while the methoxy and trifluoromethyl substituents provide orthogonal reactivity and favorable electronic modulation. Bench-stable and compatible with standard coupling protocols, it facilitates efficient construction of complex heterocyclic scaffolds and functionalized aromatic systems.

Synthesis

  • Route1

    References

    • US6521666 B1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   2.4196
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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