4-(4-Chlorothiophen-2-yl)thiazol-2-amine

Name: 4-(4-Chlorothiophen-2-yl)thiazol-2-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 570407-10-2
Cat. No. CS-0372956
Purity≥98%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(4-Chlorothiophen-2-yl)thiazol-2-amine|CS-0372956

Structure of 570407-10-2

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 570407-10-2
Cat. No. CS-0372956
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClN₂S₂
Molecular Weight 216.71
Synonym(s) 2-Thiazolamine, 4-(4-chloro-2-thienyl)-
SMILES NC1=NC(C2=CC(Cl)=CS2)=CS1

Description

This thiazole derivative features a chlorothiophene moiety that enhances electron-withdrawing character and improves metabolic stability. The amine group enables facile coupling reactions, while the fused heterocyclic system provides rigidity and planarity, favoring π-stacking in target binding. Suitable for pharmaceutical intermediates requiring halogenated aromatic scaffolds with tunable reactivity.

Application

4-(4-Chlorothiophen-2-yl)thiazol-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via cross-coupling and nucleophilic substitution reactions. Its thiazole core exhibits excellent bench stability and functional group tolerance, facilitating efficient derivatization for target-oriented synthesis. The 4-chlorothiophene moiety provides a reactive handle for Pd-catalyzed coupling, making this compound a practical intermediate in the development of bioactive molecules.

Synthesis

Route1
- 34730-20-6
- 17356-08-0
- ~%
- In-stock
  
  570407-10-2
References
- Astellas Pharma Inc. Patent: EP1647553 A1, 2006 ; Location in patent: Page/Page column 18 ;
Route2
- 677007-73-7
- 17356-08-0
- ~%
- In-stock
  
  570407-10-2
References
- YAMANOUCHI PHARMACEUTICAL CO. LTD. Patent: EP1466912 A1, 2004 ; Location in patent: Page 16 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 38.91
LogP 3.1072
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Thiophene compounds

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

4-(4-Chlorothiophen-2-yl)thiazol-2-amine sigma4-(4-Chlorothiophen-2-yl)thiazol-2-amine manufacturer4-(4-Chlorothiophen-2-yl)thiazol-2-amine price4-(4-Chlorothiophen-2-yl)thiazol-2-amine structure4-(4-Chlorothiophen-2-yl)thiazol-2-amine SDSbuy 4-(4-Chlorothiophen-2-yl)thiazol-2-amine4-(4-Chlorothiophen-2-yl)thiazol-2-amine supplier4-(4-Chlorothiophen-2-yl)thiazol-2-amine uses4-(4-Chlorothiophen-2-yl)thiazol-2-amine molecular weightprice of 4-(4-Chlorothiophen-2-yl)thiazol-2-amine4-(4-Chlorothiophen-2-yl)thiazol-2-amine chemical name formula of 4-(4-Chlorothiophen-2-yl)thiazol-2-amine

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-(4-Chlorothiophen-2-yl)thiazol-2-amine

CAS No. 570407-10-2

Recommended Products