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Structure of 56741-33-4
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5-Amino-2-fluorobenzoic acid features a strategically positioned amino group and fluorine atom on the aromatic ring, enabling enhanced electronic modulation and metabolic stability. This combination supports direct incorporation into bioactive scaffolds, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds. The carboxylic acid functionality facilitates conjugation and salt formation under standard conditions.
5-Amino-2-fluorobenzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds through standard amine and carboxylic acid transformations. Its ortho-fluoroamine functionality provides excellent regiochemical control in coupling reactions and facilitates downstream derivatization via electrophilic substitution or amidation. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for multi-step synthesis and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: