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CS-W001157 4
Total: USD 88.00

2,6-Dimethoxytoluene

  • CAS No. 5673-07-4

  • Cat. No. CS-0153507
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,6-Dimethoxytoluene|CS-0153507

Structure of 5673-07-4

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General Information

  • CAS No. 5673-07-4
  • Cat. No. CS-0153507
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂O₂
  • Molecular Weight 152.19
  • Synonym(s) 2-Methylresorcinol dimethyl ether
  • SMILES CC1=C(C=CC=C1OC)OC

Description

2,6-Dimethoxytoluene features two methoxy groups positioned ortho to the methyl substituent, enhancing electron density at the aromatic ring. This configuration supports selective functionalization in electrophilic substitution reactions and provides improved solubility in polar organic solvents. The compound exhibits bench-stable behavior under standard handling conditions.

Application

2,6-Dimethoxytoluene serves as a versatile building block in synthetic organic chemistry, offering enhanced solubility and stability due to its ortho-dimethoxy substitution. It functions effectively in electrophilic aromatic substitution and transition-metal-catalyzed coupling reactions, enabling access to complex aromatic scaffolds. The molecule’s defined regiochemistry and bench-stable nature facilitate straightforward purification and integration into multi-step syntheses.

Synthesis

  • Route1
    • In-stock
      1,3-Dimethoxybenzene|CS-W018510
      151-10-0
    • null|null
      74-88-4
    • ~88%
    • In-stock
      2,6-Dimethoxytoluene|CS-0153507
      5673-07-4

    References

    • Wyeth Patent: US2003/207927 A1, 2003 ; Location in patent: Page/Page column 19 ; US 20030207927 A1
  • Route2
    • 2,6-Dimethoxyphenyl Trifluoromethanesulfonate|CS-0757579
      60319-07-5
    • null|null
      594-27-4
    • ~94%
    • In-stock
      2,6-Dimethoxytoluene|CS-0153507
      5673-07-4

    References

    • Saa, Jose M.; Martorell, Gabriel; Garcia-Raso, Angel Journal of Organic Chemistry, 1992 , vol. 57, # 2 p. 678 - 685
  • Route3

    References

    • Boyer, Francois-Didier; Ducrot, Paul-Henri Tetrahedron Letters, 2005 , vol. 46, # 31 p. 5177 - 5180

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335-H412
Precautionary Statements : P261-P264-P271-P273-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.01222
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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