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CS-W001157 4
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5-Methoxy-2-methylphenol

  • CAS No. 20734-74-1

  • Cat. No. CS-W005841
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Methoxy-2-methylphenol|CS-W005841

Structure of 20734-74-1

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General Information

  • CAS No. 20734-74-1
  • Cat. No. CS-W005841
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀O₂
  • Molecular Weight 138.16
  • Synonym(s) Phenol, 5-methoxy-2-methyl-
  • SMILES OC1=CC(OC)=CC=C1C

Description

5-Methoxy-2-methylphenol features a methoxy group at the para position relative to a phenolic hydroxyl, combined with a methyl substituent ortho to the hydroxyl. This electron-rich aromatic scaffold enhances solubility and stability in organic media, enabling straightforward incorporation into synthetic routes for bioactive molecules and functional materials under standard conditions.

Application

5-Methoxy-2-methylphenol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted aromatic scaffolds. Its ortho-methyl and para-methoxy groups provide complementary reactivity for electrophilic substitution, Suzuki coupling, and oxidative transformations. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry campaigns and process development workflows.

Synthesis

  • Route1

    References

    • ELI LILLY AND COMPANY Patent: WO2005/37763 A1, 2005 ; Location in patent: Page/Page column 130-131 ; WO 2005/037763 A1
  • Route2

    References

    • PARADIGM THERAPEUTICS LTD. Patent: WO2007/582 A1, 2007 ; Location in patent: Page/Page column 64-65 ; WO 2007/000582 A1
  • Route3

    References

    • Dong, Suwei; Zhu, Jianglong; Porco Jr., John A. Journal of the American Chemical Society, 2008 , vol. 130, # 9 p. 2738 - 2739

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.70922
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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