2’-Deoxy-2’-fluoro-b-D-arabinocytidine

Name: 2’-Deoxy-2’-fluoro-b-D-arabinocytidine
Brand: ChemScene
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CAS No. 56632-83-8
Cat. No. CS-0186931
Purity≥97%
MDL No.MFCD07374399

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2’-Deoxy-2’-fluoro-b-D-arabinocytidine|CS-0186931

Structure of 56632-83-8

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General Information

CAS No. 56632-83-8
Cat. No. CS-0186931
Purity ≥97%
MDL No. MFCD07374399
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₂FN₃O₄
Molecular Weight 245.21
Synonym(s) 4-amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)pyrimidin-2(1H)-one
SMILES O[C@H]1[C@H](F)[C@H](N2C=CC(N)=NC2=O)O[C@@H]1CO

Description

This fluorinated nucleoside analog integrates a 2’-fluoro substitution on a β-D-arabinofuranose sugar, enhancing metabolic stability and resistance to enzymatic degradation. The arabinose configuration imparts distinct conformational rigidity, improving binding affinity in antiviral and anticancer applications.

Application

2’-Deoxy-2’-fluoro-β-D-arabinocytidine serves as a stable nucleoside analog enabling efficient incorporation into oligonucleotides via standard phosphoramidite chemistry. Its 2′-fluoro substitution enhances nuclease resistance while maintaining favorable sugar pucker conformation, facilitating robust hybridization and improved pharmacokinetic properties in antisense applications.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 110.6
LogP -1.5858
H_Acceptors 7
H_Donors 3
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

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2’-Deoxy-2’-fluoro-b-D-arabinocytidine

CAS No. 56632-83-8

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