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(6-Methylpyridin-3-yl)methanamine

  • CAS No. 56622-54-9

  • Cat. No. CS-0044724
  • Purity≥97%
  • MDL No.MFCD06212657

*For research and further manufacturing use only, not for direct human use.

(6-Methylpyridin-3-yl)methanamine|CS-0044724

Structure of 56622-54-9

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General Information

  • CAS No. 56622-54-9
  • Cat. No. CS-0044724
  • Purity ≥97%
  • MDL No. MFCD06212657
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂
  • Molecular Weight 122.17
  • Synonym(s) 3-Aminomethyl-6-methylpyridine
  • SMILES NCC1=CC=C(C)N=C1

Application

(6-Methylpyridin-3-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine scaffolds. Its primary amine functionality facilitates straightforward derivatization via amidation, alkylation, and reductive amination, while the 6-methyl group enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability, ease of purification, and compatibility with standard coupling protocols, making it well-suited for high-throughput synthesis and API development.

Synthesis

  • Route1

    References

    • Liu, Mao-Chin; Lin, Tai-Shun; Cory, Joseph G.; Cory, Ann H.; Sartorelli, Alan C. Journal of Medicinal Chemistry, 1996 , vol. 39, # 13 p. 2586 - 2593
  • Route2
    • 6-Methylnicotinamide Nicotinamide  Impurity|CS-0229410
      6960-22-1
    • ~59%
    • In-stock
      (6-Methylpyridin-3-yl)methanamine|CS-0044724
      56622-54-9

    References

    • JERINI AG Patent: WO2006/128670 A1, 2006 ; Location in patent: Page/Page column 113 ; WO 2006/128670 A1
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 69, p. 2574,2577

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.84872
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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