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CS-W001157 4
Total: USD 88.00

4-(Piperazin-1-yl)phenol

  • CAS No. 56621-48-8

  • Cat. No. CS-W017311
  • Purity≥97%
  • MDL No.MFCD00066156

*For research and further manufacturing use only, not for direct human use.

4-(Piperazin-1-yl)phenol|CS-W017311

Structure of 56621-48-8

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General Information

  • CAS No. 56621-48-8
  • Cat. No. CS-W017311
  • Purity ≥97%
  • MDL No. MFCD00066156
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄N₂O
  • Molecular Weight 178.24
  • Synonym(s) N-(4-Hydroxyphenyl)piperazine
  • SMILES OC1=CC=C(N2CCNCC2)C=C1

Description

4-(Piperazin-1-yl)phenol features a phenolic hydroxyl group flanked by a piperazine ring, delivering enhanced solubility and hydrogen-bonding capacity. This combination enables efficient integration into bioactive scaffolds, particularly in kinase inhibitors and antipsychotic leads. The molecule exhibits bench-stable behavior under standard conditions and serves as a key pharmacophore for targeted drug design.

Application

4-(Piperazin-1-yl)phenol serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient construction of diverse heterocyclic scaffolds. Its phenolic hydroxyl group facilitates direct derivatization and metal-catalyzed coupling reactions, while the piperazine moiety offers tunable basicity and hydrogen-bonding capacity. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • 1-(4-Methoxyphenyl)piperazine Miconazole  Impurity|CS-0229176
      38212-30-5
    • ~74%
    • In-stock
      4-(Piperazin-1-yl)phenol|CS-W017311
      56621-48-8

    References

    • Komoto; Okada; Sato; Niino; Oka; Sakamoto Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 10 p. 1314 - 1320
  • Route2
    • null|null
      110-85-0
    • null|null
      106-41-2
    • ~%
    • In-stock
      4-(Piperazin-1-yl)phenol|CS-W017311
      56621-48-8

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1376 - 1380

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302+H312-H314
Precautionary Statements : P264-P270-P271-P280-P304+P340-P330-P331-P363-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.5
  • LogP   0.8018
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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