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CS-W001157 4
Total: USD 88.00

3-(Piperazin-1-yl)phenol

  • CAS No. 59817-32-2

  • Cat. No. CS-0106190
  • Purity≥98%
  • MDL No.MFCD00052896

*For research and further manufacturing use only, not for direct human use.

3-(Piperazin-1-yl)phenol|CS-0106190

Structure of 59817-32-2

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General Information

  • CAS No. 59817-32-2
  • Cat. No. CS-0106190
  • Purity ≥98%
  • MDL No. MFCD00052896
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄N₂O
  • Molecular Weight 178.23
  • Synonym(s) N-(3-Hydroxyphenyl)piperazine
  • SMILES OC1=CC(N2CCNCC2)=CC=C1

Description

3-(Piperazin-1-yl)phenol features a phenolic hydroxyl group flanked by a piperazine ring, delivering enhanced solubility and tunable basicity. This combination enables effective integration into bioactive scaffolds, where the electron-rich piperazine moiety supports hydrogen bonding and metal coordination. The molecule exhibits bench-stable handling under standard conditions and serves as a key building block in medicinal chemistry.

Application

3-(Piperazin-1-yl)phenol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and cyclization protocols. Its phenolic hydroxyl group facilitates direct functionalization or protection, while the piperazine moiety offers hydrogen-bonding capacity and metabolic stability. The compound exhibits good bench stability and solubility, simplifying purification and integration into multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2923
Class : 8,6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.5
  • LogP   0.8018
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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