Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Azaphthalide

  • CAS No. 5657-51-2

  • Cat. No. CS-0030457
  • Molecule weight135.12
  • Purity≥98%
  • MDL No.MFCD01860224

*For research and further manufacturing use only, not for direct human use.

4-Azaphthalide|CS-0030457

Structure of 5657-51-2

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 5657-51-2
  • Cat. No. CS-0030457
  • Purity ≥98%
  • MDL No. MFCD01860224
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅NO₂
  • Molecular Weight 135.12
  • Synonym(s) furo[3,4-b]pyridin-5(7H)-one
  • SMILES O=C1OCC2=NC=CC=C21

Description

4-Azaphthalide features a fused bicyclic core with a nitrogen atom integrated at the 4-position, conferring enhanced electron-deficiency and polarity. This structural motif enables direct incorporation into heterocyclic scaffolds and facilitates conjugation in synthetic routes targeting bioactive compounds. The compound exhibits bench-stable handling characteristics and compatibility with standard reaction conditions.

Application

4-Azaphthalide serves as a versatile heterocyclic building block in synthetic organic chemistry, enabling efficient access to nitrogen-containing polycycles relevant to medicinal chemistry and natural product synthesis. Its fused bicyclic structure exhibits predictable reactivity in electrophilic substitution and transition-metal-catalyzed coupling reactions, with good bench stability and compatibility with common protecting groups. The molecule functions as a key scaffold for constructing bioactive compounds, particularly in the development of kinase inhibitors and antitumor agents, due to its planar geometry and defined polarity profile.

Synthesis

  • Route1
    • 2-(Hydroxymethyl)nicotinic acid|CS-0112632
      81113-14-6
    • ~90%
    • In-stock
      4-Azaphthalide|CS-0030457
      5657-51-2

    References

    • Inoue, Kunimi; Sugaya, Toru; Ogasa, Takehiro; Tomioka, Shinji Synthesis, 1997 , # 1 p. 113 - 116
  • Route2
    • 2-(Hydroxymethyl)nicotinamide|CS-0933309
      115012-11-8
    • ~72%
    • In-stock
      4-Azaphthalide|CS-0030457
      5657-51-2

    References

    • Goto, Takehiko; Saito, Minoru; Sato, Ryu Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 11 p. 4178 - 4180
  • Route3
    • null|null
      122706-38-1
    • ~71%
    • In-stock
      4-Azaphthalide|CS-0030457
      5657-51-2

    References

    • Goto, Takehiko; Konno, Michio; Saito, Minoru; Sato, Ryu Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 4 p. 1205 - 1210

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   39.19
  • LogP   0.752
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4-Azaphthalide sigma4-Azaphthalide manufacturer4-Azaphthalide price4-Azaphthalide structure4-Azaphthalide SDSbuy 4-Azaphthalide4-Azaphthalide supplier4-Azaphthalide uses4-Azaphthalide molecular weightprice of 4-Azaphthalide4-Azaphthalide chemical name formula of 4-Azaphthalide
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label