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1,1,1-Trimethoxy-2-methylpropane

  • CAS No. 52698-46-1

  • Cat. No. CS-0173471
  • Purity≥97%
  • MDL No.MFCD08276428

*For research and further manufacturing use only, not for direct human use.

1,1,1-Trimethoxy-2-methylpropane|CS-0173471

Structure of 52698-46-1

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General Information

  • CAS No. 52698-46-1
  • Cat. No. CS-0173471
  • Purity ≥97%
  • MDL No. MFCD08276428
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆O₃
  • Molecular Weight 148.20
  • Synonym(s) Trimethyl orthoisobutyrate
  • SMILES CC(C)C(OC)(OC)OC

Description

1,1,1-Trimethoxy-2-methylpropane serves as a robust protecting group for aldehydes and ketones, offering stability under a range of reaction conditions. This trialkoxy-substituted propanol derivative features high moisture tolerance and ease of handling, enabling reliable protection without side reactions. Its steric bulk facilitates selective transformations in complex molecular architectures.

Application

1,1,1-Trimethoxy-2-methylpropane serves as a stable, bench-ready silyl equivalent for the protection of alcohols and amines in complex molecule synthesis. Its trimethoxytrimethylsilyl-like reactivity enables efficient, selective derivatization under mild conditions, with excellent functional group tolerance and straightforward removal via acid-mediated deprotection. This reagent facilitates rapid access to protected intermediates in multi-step synthetic sequences, particularly in carbohydrate and natural product chemistry.

Safety Information

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GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 3272
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   1.2354
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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