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N3-Methylpyridine-2,3-diamine

  • CAS No. 56291-51-1

  • Cat. No. CS-0090257
  • Purity≥96%
  • MDL No.MFCD00490112

*For research and further manufacturing use only, not for direct human use.

N3-Methylpyridine-2,3-diamine|CS-0090257

Structure of 56291-51-1

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General Information

  • CAS No. 56291-51-1
  • Cat. No. CS-0090257
  • Purity ≥96%
  • MDL No. MFCD00490112
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃
  • Molecular Weight 123.16
  • Synonym(s) (2-amino(3-pyridyl))methylamine
  • SMILES NC1=NC=CC=C1NC

Description

N3-Methylpyridine-2,3-diamine features a pyridine core with methyl and diamine functionalities at the 3-, 2-, and 3-positions, delivering a sterically accessible, electron-rich nitrogen scaffold. This configuration enables efficient coordination in transition metal complexes and facilitates incorporation into functional ligands for catalysis and materials applications under standard conditions.

Application

N3-Methylpyridine-2,3-diamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and cyclization reactions. Its ortho-diamine functionality facilitates metal coordination and selective functionalization, while the N3-methyl group enhances stability and modulates basicity. The compound exhibits excellent bench stability and compatibility with common purification methods, making it suitable for iterative synthesis workflows in API development.

Synthesis

  • Route1
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      1353677-72-1
    • ~%
    • In-stock
      N3-Methylpyridine-2,3-diamine|CS-0090257
      56291-51-1

    References

    • TANIGUCHI, Takahiko; YOSHIKAWA, Masato; MIURA, Kasei; HASUI, Tomoaki; HONDA, Eiji; IMAMURA, Keisuke; KAMATA, Makoto; KAMISAKI, Haruhi; QUINN, John F.; RAKER, Joseph; CAMARA, Fatoumata; WANG, Yi Patent: US2011/319394 A1, 2011 ; Location in patent: Page/Page column 77 ;
  • Route2
    • null|null
      99314-92-8
    • ~93%
    • In-stock
      N3-Methylpyridine-2,3-diamine|CS-0090257
      56291-51-1

    References

    • Zecchini; Torrini; Paradisi Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 2 p. 313 - 318
  • Route3

    References

    • NOVARTIS AG; ATKINSON, Benjamin; BEATTIE, David; CULSHAW, Andrew James; DALE, James; DEVEREUX, Nicholas James; MCKENNA, Jeffrey Patent: WO2011/92293 A2, 2011 ; WO 2011/092293 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   50.94
  • LogP   0.7055
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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