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CS-W001157 4
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cis-4-Aminocyclohexanol hydrochloride

  • CAS No. 56239-26-0

  • Cat. No. CS-W019682
  • Purity≥97%
  • MDL No.MFCD07366531

*For research and further manufacturing use only, not for direct human use.

cis-4-Aminocyclohexanol hydrochloride|CS-W019682

Structure of 56239-26-0

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General Information

  • CAS No. 56239-26-0
  • Cat. No. CS-W019682
  • Purity ≥97%
  • MDL No. MFCD07366531
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄ClNO
  • Molecular Weight 151.63
  • Synonym(s) cis-4-Aminocyclohexanol hydrochloride; cis-4-Hydroxycyclohexylamine hydrochloride; Cyclohexanol,4-amino-, hydrochloride, cis-
  • SMILES O[C@@H]1CC[C@H](N)CC1.[H]Cl

Description

cis-4-Aminocyclohexanol hydrochloride offers a stable, moisture-tolerant platform for asymmetric synthesis and chiral catalyst development. The cis-configured cyclohexanol scaffold provides defined stereochemistry, while the protonated amine enhances solubility in protic solvents. This configuration supports efficient functionalization in pharmaceutical intermediates and ligand design under standard bench conditions.

Application

cis-4-Aminocyclohexanol hydrochloride serves as a valuable chiral building block in medicinal chemistry, offering a rigid, conformationally constrained scaffold with well-defined stereochemistry. The compound enables direct access to functionalized cyclohexane derivatives through standard amine and alcohol transformations, demonstrating excellent bench stability, ease of handling, and compatibility with common protection/deprotection strategies. Its dual functionality facilitates efficient synthesis of heterocyclic motifs and API intermediates under routine reaction conditions.

Synthesis

  • Route1
    • 2-Oxa-3-azabicyclo[2.2.2]oct-5-ene hydrochloride|CS-0246571
      56239-25-9
    • ~%
    • In-stock
      cis-4-Aminocyclohexanol hydrochloride|CS-W019682
      56239-26-0

    References

    • WO2007/12422 A1, ; Page/Page column 82-83 ; WO 2007/012422 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   0.6704
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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