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Structure of 5613-27-4
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5-Bromo-2,3-dimethylbenzoic acid features a bromine substituent at the 5-position paired with methyl groups at adjacent ortho positions, creating a sterically hindered, electron-deficient aromatic core. This configuration enhances stability and facilitates selective functionalization in cross-coupling reactions. The carboxylic acid group enables direct derivatization or salt formation for improved solubility in synthetic workflows.
5-Bromo-2,3-dimethylbenzoic acid serves as a versatile building block for the synthesis of substituted aromatic compounds, particularly in Suzuki-Miyaura and Stille coupling reactions. Its bromine functionality enables reliable cross-coupling under standard catalytic conditions, while the carboxylic acid group facilitates derivatization via amide or ester formation. The ortho-methyl groups provide steric shielding and enhance bench stability, contributing to straightforward purification and scalability in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Lot numbers can be found on the outside label of a product: