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CS-W001157 4
Total: USD 88.00

3,4-Dichloropyridine

  • CAS No. 55934-00-4

  • Cat. No. CS-W004811
  • Purity≥98%
  • MDL No.MFCD01861989

*For research and further manufacturing use only, not for direct human use.

3,4-Dichloropyridine|CS-W004811

Structure of 55934-00-4

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General Information

  • CAS No. 55934-00-4
  • Cat. No. CS-W004811
  • Purity ≥98%
  • MDL No. MFCD01861989
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂N
  • Molecular Weight 147.99
  • Synonym(s) Pyridine, 3,4-dichloro-; 3,4-Dichloropyridine
  • SMILES ClC1=C(C=CN=C1)Cl

Description

3,4-Dichloropyridine serves as a pivotal heterocyclic scaffold in medicinal chemistry and agrochemical synthesis. The ortho-dichloro substitution pattern imparts enhanced electrophilicity at the ring carbon positions, facilitating nucleophilic aromatic substitution reactions. This compound exhibits robust stability under standard conditions and integrates readily into complex molecular architectures via coupling processes.

Application

3,4-Dichloropyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient functionalization at the 3- and 4-positions via palladium-catalyzed cross-coupling reactions. Its dual chloro substituents offer orthogonal reactivity for sequential transformations, while the pyridine core provides excellent stability and compatibility with diverse reaction conditions. This compound functions effectively in C–H activation, nucleophilic substitution, and heterocycle elaboration workflows, facilitating rapid access to complex scaffolds used in drug discovery and materials science.

Synthesis

  • Route1

    References

    • Marzi, Elena; Bigi, Anna; Schlosser, Manfred European Journal of Organic Chemistry, 2001 , # 7 p. 1371 - 1376
  • Route2
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    • In-stock
      3,4-Dichloropyridine|CS-W004811
      55934-00-4

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 74, p. 59,67
  • Route3

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 36, p. 2244 - 2247

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3884
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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