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CS-W001157 4
Total: USD 88.00

4-Phenyl-1H-pyrazol-3-amine

  • CAS No. 5591-70-8

  • Cat. No. CS-0099425
  • Molecule weight159.19
  • Purity≥98%
  • MDL No.MFCD00231797

*For research and further manufacturing use only, not for direct human use.

4-Phenyl-1H-pyrazol-3-amine|CS-0099425

Structure of 5591-70-8

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General Information

  • CAS No. 5591-70-8
  • Cat. No. CS-0099425
  • Purity ≥98%
  • MDL No. MFCD00231797
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉N₃
  • Molecular Weight 159.19
  • Synonym(s) None
  • SMILES NC1=NNC=C1C2=CC=CC=C2

Description

4-Phenyl-1H-pyrazol-3-amine integrates a phenyl-substituted pyrazole core with a primary amine at the 3-position, offering a rigid, electron-rich scaffold for medicinal chemistry. This bench-stable heterocycle serves as a key building block in bioactive molecule design, particularly in kinase inhibitors and CNS-targeted compounds.

Application

4-Phenyl-1H-pyrazol-3-amine serves as a versatile scaffold for medicinal chemistry and materials science, enabling efficient construction of bioactive heterocycles. Its phenyl-substituted pyrazole core exhibits robust bench stability and tolerates diverse functional groups, facilitating coupling reactions and cyclization protocols. The primary amine functionality provides a direct handle for derivatization, supporting modular synthesis of kinase inhibitors, antiviral agents, and advanced organic semiconductors.

Synthesis

  • Route1
    • null|null
      18226-53-4
    • ~67%
    • In-stock
      4-Phenyl-1H-pyrazol-3-amine|CS-0099425
      5591-70-8

    References

    • Anwar, Hany Fakhry; Fleita, Daisy Hanna; Kolshorn, Heinz; Meier, Herbert; Elnagdi, Mohamed Hilmy Arkivoc, 2006 , vol. 2006, # 15 p. 133 - 141
  • Route2
    • null|null
      5841-70-3
    • ~%
    • In-stock
      4-Phenyl-1H-pyrazol-3-amine|CS-0099425
      5591-70-8

    References

    • US4824834 A1, ;
  • Route3
    • null|null
      57488-21-8
    • ~95%
    • In-stock
      4-Phenyl-1H-pyrazol-3-amine|CS-0099425
      5591-70-8

    References

    • Salaheldin, Abdellatif M.; Alphy, Maryana K. Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 2 p. 307 - 310

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.6589
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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