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CS-W001157 4
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Methyl 5-(bromomethyl)picolinate

  • CAS No. 55876-84-1

  • Cat. No. CS-W018767
  • Purity≥96%
  • MDL No.MFCD07367952

*For research and further manufacturing use only, not for direct human use.

Methyl 5-(bromomethyl)picolinate|CS-W018767

Structure of 55876-84-1

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General Information

  • CAS No. 55876-84-1
  • Cat. No. CS-W018767
  • Purity ≥96%
  • MDL No. MFCD07367952
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrNO₂
  • Molecular Weight 230.06
  • Synonym(s) METHYL-5-BROMOMETHYLPYRIDINE-2-CARBOXYLATE
  • SMILES O=C(OC)C1=NC=C(CBr)C=C1

Description

Methyl 5-(bromomethyl)picolinate features a bromomethyl group appended to the pyridine ring, enabling direct functionalization at the C5 position. This electrophilic handle facilitates efficient coupling reactions in synthetic workflows, particularly in the construction of complex heterocycles and bioconjugates. The methyl ester provides compatibility with standard reduction and amidation protocols.

Application

Methyl 5-(bromomethyl)picolinate serves as a versatile building block for constructing pyridine-based heterocycles and bioactive scaffolds. The bromomethyl group enables efficient nucleophilic substitution, facilitating C–C and C–heteroatom bond formation under mild conditions. Its stability under standard bench handling and compatibility with diverse functional groups make it ideal for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.7631
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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