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CS-W001157 4
Total: USD 88.00

5-Bromothiophene-2-sulfonyl chloride

  • CAS No. 55854-46-1

  • Cat. No. CS-W014064
  • Purity≥95%
  • MDL No.MFCD00084909

*For research and further manufacturing use only, not for direct human use.

5-Bromothiophene-2-sulfonyl chloride|CS-W014064

Structure of 55854-46-1

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General Information

  • CAS No. 55854-46-1
  • Cat. No. CS-W014064
  • Purity ≥95%
  • MDL No. MFCD00084909
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂BrClO₂S₂
  • Molecular Weight 261.53
  • Synonym(s) 5-bromothiophene-2-sulfonylchloride
  • SMILES O=S(C1=CC=C(Br)S1)(Cl)=O

Description

5-Bromothiophene-2-sulfonyl chloride features a brominated thiophene core paired with a reactive sulfonyl chloride group, enabling direct incorporation into sulfonamide derivatives. The electron-deficient thiophene ring enhances electrophilic reactivity, while the bench-stable sulfonyl chloride facilitates efficient coupling under mild conditions. This compound serves as a key building block for functionalized heterocycles in medicinal chemistry and materials science.

Application

5-Bromothiophene-2-sulfonyl chloride serves as a versatile building block for the synthesis of sulfonamide-containing heterocycles and functionalized thiophene derivatives. Its reactivity enables efficient coupling with amines and nucleophiles under mild conditions, facilitating access to medicinally relevant scaffolds. The molecule exhibits good bench stability and compatibility with common protecting groups, supporting its use in multi-step synthetic sequences.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314-H317
Precautionary Statements : P260-P261-P264-P272-P280-P301+P330+P331-P302+P352-P304+P340-P362+P364-P363-P405-P501

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   2.4381
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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