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CS-W001157 4
Total: USD 88.00

5-Bromothiophene-2-sulfonyl chloride

  • CAS No. 55854-46-1

  • Cat. No. CS-W014064
  • Purity≥95%
  • MDL No.MFCD00084909
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromothiophene-2-sulfonyl chloride|CS-W014064

Structure of 55854-46-1

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Description

5-Bromothiophene-2-sulfonyl chloride features a brominated thiophene core paired with a reactive sulfonyl chloride group, enabling direct incorporation into sulfonamide derivatives. The electron-deficient thiophene ring enhances electrophilic reactivity, while the bench-stable sulfonyl chloride facilitates efficient coupling under mild conditions. This compound serves as a key building block for functionalized heterocycles in medicinal chemistry and materials science.

Application

5-Bromothiophene-2-sulfonyl chloride serves as a versatile building block for the synthesis of sulfonamide-containing heterocycles and functionalized thiophene derivatives. Its reactivity enables efficient coupling with amines and nucleophiles under mild conditions, facilitating access to medicinally relevant scaffolds. The molecule exhibits good bench stability and compatibility with common protecting groups, supporting its use in multi-step synthetic sequences.

General Information

  • CAS No. 55854-46-1
  • Cat. No. CS-W014064
  • Purity ≥95%
  • MDL No. MFCD00084909
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂BrClO₂S₂
  • Molecular Weight 261.53
  • Synonym(s) 5-bromothiophene-2-sulfonylchloride
  • SMILES O=S(C1=CC=C(Br)S1)(Cl)=O

Computational Chemistry Data

  • TPSA   34.14
  • LogP   2.4381
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group :
Hazard Statements : H314-H317
Precautionary Statements : P260-P261-P264-P272-P280-P301+P330+P331-P302+P352-P304+P340-P362+P364-P363-P405-P501

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