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CS-W001157 4
Total: USD 88.00

4-Chloro-7-(3-chloropropoxy)quinazoline

  • CAS No. 557770-90-8

  • Cat. No. CS-0170816
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chloro-7-(3-chloropropoxy)quinazoline|CS-0170816

Structure of 557770-90-8

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General Information

  • CAS No. 557770-90-8
  • Cat. No. CS-0170816
  • Purity ≥98%
  • MDL No. None
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀Cl₂N₂O
  • Molecular Weight 257.12
  • Synonym(s) None
  • SMILES C(CCl)COC1=CC2=NC=NC(=C2C=C1)Cl

Synthesis

  • Route1

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2004/105764 A1, 2004 ; Location in patent: Page 42-43 ; WO 2004/105764 A1
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 50, # 9 p. 2213 - 2224
  • Route3
    • 2-Amino-4-fluorobenzoic acid Afatinib Impurity|CS-0167288
      446-32-2
    • ~%
    • 4-Chloro-7-(3-chloropropoxy)quinazoline|CS-0170816
      557770-90-8

    References

    • Chemical Biology and Drug Design, , vol. 81, # 3 p. 399 - 407

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.01
  • LogP   3.2909
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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