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CS-W001157 4
Total: USD 88.00

1-(Benzyloxy)-4-(bromomethyl)benzene

  • CAS No. 5544-60-5

  • Cat. No. CS-0696117
  • Molecule weight277.16
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Benzyloxy)-4-(bromomethyl)benzene|CS-0696117

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General Information

  • CAS No. 5544-60-5
  • Cat. No. CS-0696117
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₃BrO
  • Molecular Weight 277.16
  • Synonym(s) None
  • SMILES BrCC1=CC=C(OCC2=CC=CC=C2)C=C1

Description

1-(Benzyloxy)-4-(bromomethyl)benzene features a benzyloxy group and a bromomethyl moiety on opposite ends of a benzene ring, enabling orthogonal functionalization. This bifunctional scaffold facilitates selective coupling reactions in synthetic organic chemistry, particularly in the construction of complex molecular architectures. The bromomethyl handle undergoes efficient nucleophilic substitution, while the benzyloxy group remains stable under standard reaction conditions.

Application

1-(Benzyloxy)-4-(bromomethyl)benzene serves as a versatile bifunctional building block, enabling efficient coupling strategies in medicinal chemistry and materials synthesis. The benzyloxy group provides orthogonal protection for phenolic functionalities, while the bromomethyl moiety facilitates reliable SN2 reactions, Suzuki couplings, and transition-metal-catalyzed transformations. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex aryl architectures and functionalized scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   4.1605
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   4

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