2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol

Name: 2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol
Brand: ChemScene
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CAS No. 5521-39-1
Cat. No. CS-0157481
Purity≥98%
MDL No.MFCD00702247

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol|CS-0157481

Structure of 5521-39-1

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General Information

CAS No. 5521-39-1
Cat. No. CS-0157481
Purity ≥98%
MDL No. MFCD00702247
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₉N₃O
Molecular Weight 221.30
Synonym(s) None
SMILES OCCN1CCN(C2=CC=C(N)C=C2)CC1

Description

This piperazine-based scaffold integrates a para-aminophenyl moiety with a terminal hydroxylethyl group, enabling versatile conjugation and solubility enhancement in medicinal chemistry applications. The amine functionality supports derivatization, while the hydroxyl group facilitates hydrogen bonding and improved aqueous compatibility.

Application

2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol serves as a versatile bifunctional building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds. Its piperazine core provides enhanced solubility and metabolic stability, while the primary amine and hydroxyl groups offer orthogonal handles for conjugation and derivatization. The molecule exhibits excellent bench stability and compatibility with standard coupling protocols, facilitating efficient synthesis of targeted bioactive compounds.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P264-P280-P305+P351+P338-P337+P313

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Computational Chemistry Data

TPSA 52.73
LogP 0.3831
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol

CAS No. 5521-39-1

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