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CS-W001157 4
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L-Proline tert-butyl ester hydrochloride

  • CAS No. 5497-76-7

  • Cat. No. CS-W015256
  • Molecule weight207.70
  • Purity≥95%
  • MDL No.MFCD00153459

*For research and further manufacturing use only, not for direct human use.

L-Proline tert-butyl ester hydrochloride|CS-W015256

Structure of 5497-76-7

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General Information

  • CAS No. 5497-76-7
  • Cat. No. CS-W015256
  • Purity ≥95%
  • MDL No. MFCD00153459
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₈ClNO₂
  • Molecular Weight 207.70
  • Synonym(s) tert-Butyl L-prolinate (hydrochloride)
  • SMILES CC(C)(OC([C@]1([H])CCCN1)=O)C.Cl

Description

L-Proline tert-butyl ester hydrochloride offers a stable, bench-ready form of proline for peptide synthesis and medicinal chemistry. The tert-butyl ester group enables selective protection, while the hydrochloride salt enhances solubility and handling. This derivative integrates seamlessly into coupling protocols under standard conditions.

Application

L-Proline tert-butyl ester (hydrochloride) serves as a robust chiral building block in asymmetric synthesis, enabling efficient construction of proline-derived scaffolds. Its stable tert-butyl ester group facilitates straightforward purification and orthogonal protection strategies, while the hydrochloride salt enhances solubility and handling. This derivative functions effectively in peptide coupling, catalytic asymmetric reactions, and heterocycle formation, offering reliable performance in both laboratory-scale syntheses and process chemistry applications.

Synthesis

  • Route1
    • null|null
      115-11-7
    • L-Proline Enalapril  Impurity|CS-0229432
      147-85-3
    • ~47%
    • In-stock
      L-Proline tert-butyl ester hydrochloride|CS-W015256
      5497-76-7

    References

    • Tetrahedron, , vol. 41, # 23 p. 5633 - 5636
  • Route2
    • Boc-Pyr-OtBu|CS-0915008
      91237-84-2
    • ~%
    • In-stock
      L-Proline tert-butyl ester hydrochloride|CS-W015256
      5497-76-7

    References

    • Journal of Organic Chemistry, , vol. 59, # 11 p. 3216 - 3218
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 59, # 11 p. 3216 - 3218

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.5019
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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