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CS-W001157 4
Total: USD 88.00

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine

  • CAS No. 54903-50-3

  • Cat. No. CS-W018311
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine|CS-W018311

Structure of 54903-50-3

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General Information

  • CAS No. 54903-50-3
  • Cat. No. CS-W018311
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NS
  • Molecular Weight 139.22
  • Synonym(s) 4,5,6,7-hexahydrothieno[3,2-c]pyridine
  • SMILES C1(C=CS2)=C2CCNC1

Description

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine is a heterocyclic scaffold featuring a saturated thiophene fused to a pyridine ring, offering enhanced stability and tunable electronic properties. This core structure integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for compounds targeting CNS disorders and kinase pathways.

Application

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its saturated thienopyridine core exhibits favorable bench stability and functional group tolerance, enabling straightforward derivatization via electrophilic substitution or transition-metal-catalyzed coupling. The scaffold provides a rigid, planar framework suitable for probing structure-activity relationships in kinase inhibitors and other bioactive molecules.

Synthesis

  • Route1
    • 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride Clopidogrel Impurity|CS-0213926
      28783-41-7
    • ~97%
    • In-stock
      4,5,6,7-Tetrahydrothieno[3,2-c]pyridine|CS-W018311
      54903-50-3

    References

    • SANDOZ AG Patent: WO2009/80469 A1, 2009 ; Location in patent: Page/Page column 10 ;
  • Route2
    • null|null
      1453099-81-4
    • ~59%
    • In-stock
      4,5,6,7-Tetrahydrothieno[3,2-c]pyridine|CS-W018311
      54903-50-3

    References

    • Nguyen, Hai; Khatri, Hem Raj; Zhu, Jianglong Tetrahedron Letters, 2013 , vol. 54, # 40 p. 5464 - 5466
  • Route3

    References

    • Meiji Seika Kaisha, Ltd. Patent: US6498251 B1, 2002 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.3938
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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