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CS-W001157 4
Total: USD 88.00

3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate Tofacitinib Impurity

  • CAS No. 540737-29-9

  • Cat. No. CS-0167103
  • Purity≥98%
  • MDL No.MFCD11616529

*For research and further manufacturing use only, not for direct human use.

3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate Tofacitinib Impurity|CS-0167103

Structure of 540737-29-9

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General Information

  • CAS No. 540737-29-9
  • Cat. No. CS-0167103
  • Purity ≥98%
  • MDL No. MFCD11616529
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₂₈N₆O₈
  • Molecular Weight 504.49
  • Synonym(s) Tofacitinib Citrate
  • SMILES N#CCC(N1C[C@@H]([C@@H](CC1)C)N(C2=C3C(NC=C3)=NC=N2)C)=O.O=C(O)CC(O)(CC(O)=O)C(O)=O

Description

Inhibiting JAK1 and JAK3 kinase activity through competitive ATP binding, Tofacitinib citrate (CAS 540737-29-9) suppresses downstream STAT signaling cascades in immune cell populations.

Application

Tofacitinib citrate (CAS 540737-29-9) drives human serum albumin interaction studies through fluorescence quenching and dynamic light scattering, revealing binding thermodynamics in real time. It stabilizes protein conformation during differential scanning calorimetry. Researchers leverage this to assess cytokine-induced proteoglycan degradation in full-depth articular cartilage explants. In MCF7 breast cancer cells, it potently inhibits Janus kinase signaling pathways.

Safety Information

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GHS Pictogram :
GHS No : GHS07,GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H361
Precautionary Statements : P264-P270-P280-P405-P501

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Computational Chemistry Data

  • TPSA   221.04
  • LogP   0.29628
  • H_Acceptors   9
  • H_Donors   5
  • Rotatable_Bonds   8

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