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Structure of 540737-29-9
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Inhibiting JAK1 and JAK3 kinase activity through competitive ATP binding, Tofacitinib citrate (CAS 540737-29-9) suppresses downstream STAT signaling cascades in immune cell populations.
Tofacitinib citrate (CAS 540737-29-9) drives human serum albumin interaction studies through fluorescence quenching and dynamic light scattering, revealing binding thermodynamics in real time. It stabilizes protein conformation during differential scanning calorimetry. Researchers leverage this to assess cytokine-induced proteoglycan degradation in full-depth articular cartilage explants. In MCF7 breast cancer cells, it potently inhibits Janus kinase signaling pathways.
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GHS Pictogram :
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GHS No : GHS07,GHS08
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H361
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Precautionary Statements : P264-P270-P280-P405-P501
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Lot numbers can be found on the outside label of a product: