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CS-W001157 4
Total: USD 88.00

Dimethyl 4-chloropyridine-2,6-dicarboxylate

  • CAS No. 5371-70-0

  • Cat. No. CS-W006713
  • Purity≥96%
  • MDL No.MFCD02612781

*For research and further manufacturing use only, not for direct human use.

Dimethyl 4-chloropyridine-2,6-dicarboxylate|CS-W006713

Structure of 5371-70-0

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General Information

  • CAS No. 5371-70-0
  • Cat. No. CS-W006713
  • Purity ≥96%
  • MDL No. MFCD02612781
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈ClNO₄
  • Molecular Weight 229.62
  • Synonym(s) None
  • SMILES O=C(C1=NC(C(OC)=O)=CC(Cl)=C1)OC

Description

Dimethyl 4-chloropyridine-2,6-dicarboxylate features a pyridine core bearing chloro and ester functionalities at the 4-, 2-, and 6-positions, enabling efficient integration into heterocyclic syntheses. The electron-deficient pyridine ring facilitates nucleophilic substitution, while the bench-stable dimethyl ester groups support straightforward functionalization under standard conditions.

Application

Dimethyl 4-chloropyridine-2,6-dicarboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient construction of pyridine-based scaffolds through nucleophilic substitution and coupling reactions. The 4-chloro group exhibits high reactivity toward amines, thiols, and organometallic reagents, while the flanking ester functionalities allow for selective transformations. Its bench-stable nature and compatibility with standard purification methods make it ideal for iterative synthetic sequences in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.49
  • LogP   1.3082
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   2

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