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CS-W001157 4
Total: USD 88.00

4-Bromo-2,3,6-trifluorobenzaldehyde

  • CAS No. 537033-56-0

  • Cat. No. CS-W022090
  • Purity≥98%
  • MDL No.MFCD03094468

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2,3,6-trifluorobenzaldehyde|CS-W022090

Structure of 537033-56-0

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General Information

  • CAS No. 537033-56-0
  • Cat. No. CS-W022090
  • Purity ≥98%
  • MDL No. MFCD03094468
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₂BrF₃O
  • Molecular Weight 238.99
  • Synonym(s) None
  • SMILES O=CC1=C(F)C=C(Br)C(F)=C1F

Description

4-Bromo-2,3,6-trifluorobenzaldehyde features a strategically positioned bromine atom and three fluorine substituents that collectively enhance electronic withdrawal and metabolic stability. This electron-deficient aromatic aldehyde integrates readily into cross-coupling reactions and serves as a key building block for pharmaceutical intermediates and functional materials.

Application

4-Bromo-2,3,6-trifluorobenzaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling efficient construction of fluorinated heterocycles and pharmaceutical scaffolds. Its reactivity is well-documented in cross-coupling processes, including Suzuki-Miyaura and Buchwald-Hartwig reactions, facilitated by the orthogonal reactivity of the aldehyde and halogen functional groups. The molecule exhibits excellent bench stability and compatibility with standard purification methods, making it ideal for multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.6789
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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