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CS-W001157 4
Total: USD 88.00

Methyl 2-amino-2-cyclopropylacetate hydrochloride

  • CAS No. 535936-86-8

  • Cat. No. CS-W005014
  • Molecule weight165.62
  • Purity≥95%
  • MDL No.MFCD12031219

*For research and further manufacturing use only, not for direct human use.

Methyl 2-amino-2-cyclopropylacetate hydrochloride|CS-W005014

Structure of 535936-86-8

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General Information

  • CAS No. 535936-86-8
  • Cat. No. CS-W005014
  • Purity ≥95%
  • MDL No. MFCD12031219
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClNO₂
  • Molecular Weight 165.62
  • Synonym(s) None
  • SMILES COC(C(N)C1CC1)=O.Cl

Description

Methyl 2-amino-2-cyclopropylacetate hydrochloride features a sterically hindered cyclopropyl group adjacent to a primary amine, enabling robust coupling reactions. The hydrochloride salt enhances solubility and stability under standard conditions, facilitating efficient incorporation into peptide-like scaffolds and medicinal chemistry libraries.

Application

Methyl 2-amino-2-cyclopropylacetate hydrochloride serves as a versatile building block for synthesizing cyclopropyl-containing bioactive molecules. Its amino and ester functionalities enable straightforward derivatization via amidation, alkylation, and reductive amination. The hydrochloride salt enhances bench stability and solubility, facilitating purification and integration into standard peptide-like or heterocyclic synthesis workflows.

Synthesis

  • Route1
    • Cyclopropylglycine|CS-0440195
      10294-18-5
    • ~86%
    • In-stock
      Methyl 2-amino-2-cyclopropylacetate hydrochloride|CS-W005014
      535936-86-8

    References

    • Verhoest, Patrick R.; Hoffman, Robert Louis; Corbett, Jeffrey W.; Ennis, Michael Dalton; Frank, Kristine E.; Fu, Jian-Min Patent: US2003/144297 A1, 2003 ; US 20030144297 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.3185
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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