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CS-W001157 4
Total: USD 88.00

1-(Isopropylsulfonyl)piperazine

  • CAS No. 534615-34-4

  • Cat. No. CS-0453431
  • Molecule weight192.28
  • Purity≥95%
  • MDL No.MFCD09743769

*For research and further manufacturing use only, not for direct human use.

1-(Isopropylsulfonyl)piperazine|CS-0453431

Structure of 534615-34-4

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General Information

  • CAS No. 534615-34-4
  • Cat. No. CS-0453431
  • Purity ≥95%
  • MDL No. MFCD09743769
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆N₂O₂S
  • Molecular Weight 192.28
  • Synonym(s) 1-(PROPANE-2-SULFONYL)-PIPERAZINE
  • SMILES CC(C)S(=O)(=O)N1CCNCC1

Description

1-(Isopropylsulfonyl)piperazine features a sulfonamide group attached to a piperazine core, delivering enhanced solubility and metabolic stability. This structural motif enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS modulators. The isopropyl substituent contributes steric bulk and lipophilic character, fine-tuning molecular properties for optimized target engagement and pharmacokinetics.

Application

1-(Isopropylsulfonyl)piperazine serves as a versatile sulfonamide-containing building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amide and Suzuki coupling protocols. Its isopropylsulfonyl group imparts enhanced metabolic stability and solubility, while the piperazine core offers multiple sites for derivatization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for high-throughput synthesis and API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   49.41
  • LogP   -0.3702
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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