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Structure of 534615-34-4
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1-(Isopropylsulfonyl)piperazine features a sulfonamide group attached to a piperazine core, delivering enhanced solubility and metabolic stability. This structural motif enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS modulators. The isopropyl substituent contributes steric bulk and lipophilic character, fine-tuning molecular properties for optimized target engagement and pharmacokinetics.
1-(Isopropylsulfonyl)piperazine serves as a versatile sulfonamide-containing building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amide and Suzuki coupling protocols. Its isopropylsulfonyl group imparts enhanced metabolic stability and solubility, while the piperazine core offers multiple sites for derivatization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for high-throughput synthesis and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362
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Lot numbers can be found on the outside label of a product: