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CS-W001157 4
Total: USD 88.00

2,4-Dimethylthiazole-5-carboxylic acid

  • CAS No. 53137-27-2

  • Cat. No. CS-W002255
  • Purity≥98%
  • MDL No.MFCD00052943

*For research and further manufacturing use only, not for direct human use.

2,4-Dimethylthiazole-5-carboxylic acid|CS-W002255

Structure of 53137-27-2

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General Information

  • CAS No. 53137-27-2
  • Cat. No. CS-W002255
  • Purity ≥98%
  • MDL No. MFCD00052943
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂S
  • Molecular Weight 157.19
  • Synonym(s) None
  • SMILES CC1=NC(C)=C(C(O)=O)S1

Description

2,4-Dimethylthiazole-5-carboxylic acid features a fused heterocyclic core with dual methyl substitutions enhancing electronic density and steric profile. The carboxylic acid group enables direct conjugation in synthetic transformations, while the thiazole scaffold imparts metabolic stability and solubility under standard conditions. This compound serves as a key building block for bioactive molecule synthesis.

Application

2,4-Dimethylthiazole-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of thiazole-based heterocycles via standard coupling and cyclization protocols. Its carboxylic acid functionality facilitates direct amidation, esterification, and derivatization under mild conditions. The molecule exhibits good bench stability and functional group tolerance, supporting efficient purification and scalability in process development workflows.

Synthesis

  • Route1

    References

    • Justus Liebigs Annalen der Chemie, , vol. 259, p. 266
  • Route2

    References

    • Zhurnal Obshchei Khimii, , vol. 26, p. 66; engl. Ausg. S. 65
  • Route3

    References

    • Proceedings - Indian Academy of Sciences, Section A, , # 22 p. 362,376

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.45814
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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