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CS-W001157 4
Total: USD 88.00

4-Hydroxy-3-methylanisol

  • CAS No. 5307-05-1

  • Cat. No. CS-W006115
  • Purity≥98%
  • MDL No.MFCD11055138

*For research and further manufacturing use only, not for direct human use.

4-Hydroxy-3-methylanisol|CS-W006115

Structure of 5307-05-1

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General Information

  • CAS No. 5307-05-1
  • Cat. No. CS-W006115
  • Purity ≥98%
  • MDL No. MFCD11055138
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀O₂
  • Molecular Weight None
  • Synonym(s) 4-Methoxy-2-methylphenol
  • SMILES COC1=CC=C(O)C(C)=C1

Description

4-Hydroxy-3-methylanisol offers a strategically positioned phenolic hydroxyl and methyl group, enabling direct functionalization in synthetic sequences. This electron-rich scaffold enhances reactivity in coupling reactions and serves as a key intermediate for bioactive molecule synthesis under standard bench conditions.

Application

4-Hydroxy-3-methylanisol serves as a versatile phenolic building block in synthetic organic chemistry, enabling efficient derivatization via hydroxyl group functionalization. Its ortho-methyl substitution enhances stability and facilitates electrophilic aromatic substitution reactions. The compound functions effectively in coupling protocols and acts as a key scaffold for heterocyclic systems and bioactive molecule synthesis.

Synthesis

  • Route1

    References

    • KARO BIO AB Patent: WO2009/124968 A1, 2009 ; Location in patent: Page/Page column 29 ;
  • Route2
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      23562-77-8
    • ~%
    • In-stock
      4-Hydroxy-3-methylanisol|CS-W006115
      5307-05-1

    References

    • Reeve; Sadle Journal of the American Chemical Society, 1950 , vol. 72, p. 3252
  • Route3
    • null|null
      127136-79-2
    • ~87%
    • In-stock
      4-Hydroxy-3-methylanisol|CS-W006115
      5307-05-1

    References

    • Clark, Richard F.; Zhang, Tianyuan; Wang, Xiaojun; Wang, Rongqi; Zhang, Xiaolin; Camp, Heidi S.; Beutel, Bruce A.; Sham, Hing L.; Gu, Yu Gui Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 1961 - 1965

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P301+P310-P302+P352-P305+P351+P338-P330-P332+P313-P337+P313-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.70922
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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