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CS-W001157 4
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4-Methoxy-3-methylphenol

  • CAS No. 14786-82-4

  • Cat. No. CS-0059284
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Methoxy-3-methylphenol|CS-0059284

Structure of 14786-82-4

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General Information

  • CAS No. 14786-82-4
  • Cat. No. CS-0059284
  • Purity ≥98%
  • MDL No. None
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀O₂
  • Molecular Weight 138.16
  • Synonym(s) methoxy-3-methyl-phenol
  • SMILES OC1=CC=C(OC)C(C)=C1

Description

4-Methoxy-3-methylphenol offers a distinctive combination of electron-donating methoxy and methyl groups positioned ortho to the phenolic hydroxyl, enhancing reactivity in electrophilic substitution. This structural motif enables direct incorporation into advanced synthetic intermediates for pharmaceuticals and specialty materials.

Application

4-Methoxy-3-methylphenol serves as a versatile phenolic building block in synthetic organic chemistry, enabling efficient access to substituted aromatics and heterocycles. Its ortho-methyl and para-methoxy groups provide directed electrophilic substitution patterns and enhance stability during functionalization. The compound exhibits excellent bench stability, facilitates straightforward purification, and functions effectively in coupling reactions and cyclization protocols common in pharmaceutical and agrochemical synthesis.

Synthesis

  • Route1

    References

    • Lecornue, Frederic; Ollivier, Jean Synlett, 2004 , # 9 p. 1613 - 1615
  • Route2

    References

    • Roy, Amalesh; Biswas, Bidyut; Sen, Prabir K.; Venkateswaran, Ramanathapuram V. Tetrahedron Letters, 2007 , vol. 48, # 39 p. 6933 - 6936
  • Route3
    • null|null
      13522-78-6
    • ~85%
    • In-stock
      4-Methoxy-3-methylphenol|CS-0059284
      14786-82-4

    References

    • Hauser, Frank M.; Ganguly, Debashis Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1842 - 1849

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.70922
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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