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CS-W001157 4
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Ethyl 3-aminobutyrate

  • CAS No. 5303-65-1

  • Cat. No. CS-0030781
  • Purity≥97%
  • MDL No.MFCD00008086

*For research and further manufacturing use only, not for direct human use.

Ethyl 3-aminobutyrate|CS-0030781

Structure of 5303-65-1

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General Information

  • CAS No. 5303-65-1
  • Cat. No. CS-0030781
  • Purity ≥97%
  • MDL No. MFCD00008086
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃NO₂
  • Molecular Weight None
  • Synonym(s) Ethyl-3-aminobutyrate
  • SMILES CC(CC(OCC)=O)N

Description

Ethyl 3-aminobutyrate serves as a key building block in synthetic organic chemistry, featuring a primary amine group flanked by an ethyl ester and a β-carbon. This combination enables direct functionalization at the nitrogen and selective derivatization of the ester moiety. The molecule exhibits favorable solubility in common organic solvents and maintains stability under standard bench conditions, facilitating its use in peptide-like scaffolds and heterocyclic synthesis.

Application

Ethyl 3-aminobutyrate serves as a versatile building block in synthetic organic chemistry, enabling the construction of heterocyclic scaffolds and bioactive intermediates. Its amine and ester functionalities offer orthogonal reactivity for sequential transformations, while its bench-stable nature facilitates handling and purification. The compound functions effectively in Mannich reactions, acylations, and coupling protocols, providing access to diverse molecular architectures relevant to medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Bartoli; Cimarelli; Marcantoni; Palmieri; Petrini Journal of Organic Chemistry, 1994 , vol. 59, # 18 p. 5328 - 5335
  • Route2
    • Ethyl 3-(benzylamino)butanoate|CS-0361483
      6335-80-4
    • ~93%
    • In-stock
      Ethyl 3-aminobutyrate|CS-0030781
      5303-65-1

    References

    • N'Goka; Schlewer; Linget; Chambon; Wermuth Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2547 - 2557
  • Route3

    References

    • EP1932824 A1, ; Page/Page column 25; 26; 27 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Warning
UN#: 3272
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.2868
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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