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Structure of 52833-94-0
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2-Amino-5-bromonicotinic acid features a bromine atom at the 5-position and an amino group at the 2-position of the nicotinic acid scaffold, delivering a potent electron-deficient heterocyclic core. This configuration enables direct incorporation into pharmaceutical intermediates and bioactive molecule scaffolds requiring halogenated pyridine motifs. The compound exhibits enhanced reactivity in cross-coupling processes and offers improved solubility in polar solvents compared to analogs.
2-Amino-5-bromonicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of brominated heterocyclic scaffolds via standard coupling and cyclization protocols. Its ortho-amino and bromine substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling and directed metalation, facilitating efficient access to complex nitrogen-containing frameworks. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring precise regiocontrol.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: